THE HETEROGENEITY OF THE OSTEOPETROSES REFLECTS THE DIVERSITY OF CELLULAR INFLUENCES DURING SKELETAL DEVELOPMENT

被引：39

作者：

POPOFF, SN

MARKS, SC

机构：

[1] UNIV MASSACHUSETTS, MED CTR, DEPT CELL BIOL, WORCESTER, MA 01655 USA

[2] TEMPLE UNIV, SCH MED, DEPT ANAT & CELL BIOL, PHILADELPHIA, PA 19122 USA

来源：

BONE | 1995年 / 17卷 / 05期

关键词：

SKELETON; GROWTH FACTORS; ONCOGENES; CYTOKINES; OSTEOPETROSIS;

D O I：

10.1016/8756-3282(95)00347-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Experimental studies of the mammalian osteopetroses, characterized by generalized skeletal sclerosis, have illuminated a variety of mechanisms by which bone resorption can be reduced, We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.

引用

页码：437 / 445

页数：9

共 131 条

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