TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) INCREASES BOTH IN THE BRAIN AND IN THE CEREBROSPINAL-FLUID FROM PARKINSONIAN-PATIENTS

被引：835

作者：

MOGI, M

HARADA, M

RIEDERER, P

NARABAYASHI, H

FUJITA, K

NAGATSU, T

机构：

[1] MATSUMOTO DENT COLL,DEPT ORAL BIOCHEM,SHIOJIRI,JAPAN

[2] UNIV WURZBURG,DEPT PSYCHIAT,W-8700 WURZBURG,GERMANY

[3] JUNTENDO UNIV,SCH MED,TOKYO,TOKYO 113,JAPAN

[4] FUJITA HLTH UNIV,SCH MED,INST COMPREHENS MED SCI,TOYOAKE,AICHI 47011,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 165卷 / 1-2期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; PARKINSONS DISEASE; STRIATUM; CEREBROSPINAL FLUID;

D O I：

10.1016/0304-3940(94)90746-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tumor necrosis factor-alpha (TNF-alpha), a glial-cell-related factor, was measured for the first time in the brain (striatum) and cerebrospinal fluid (CSF) from control and parkinsonian patients by a sensitive sandwich enzyme immunoassay. The concentrations of TNF-alpha in the brain and CSF were significantly higher in parkinsonian patients than those in controls. Since TNF-alpha is an important signal transducer of the immune system with cytotoxic and stimulator properties, these results suggest that an immune response may occur in the nigrostriatal dopaminergic regions in Parkinson's disease and that TNF-alpha may be related, at least in part, to the neuronal degeneration.

引用

页码：208 / 210

页数：3

共 19 条

[1]

BALKWILL FR, 1989, IMMUNOL TODAY, V10, P229

[2]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[3] HYPOTHESIS - A ROLE FOR TUMOR NECROSIS FACTOR IN IMMUNE-MEDIATED DEMYELINATION AND ITS RELEVANCE TO MULTIPLE-SCLEROSIS [J].