EFFECTS OF ANTI-TRIADIN ANTIBODY ON CA2+ RELEASE FROM SARCOPLASMIC-RETICULUM

被引：44
|
作者：
BRANDT, NR
CASWELL, AH
BRUNSCHWIG, JP
KANG, JJ
ANTONIU, B
IKEMOTO, N
机构：
[1] BOSTON BIOMED RES INST,DEPT MUSCLE RES,BOSTON,MA 02114
[2] UNIV MIAMI,SCH MED,DEPT PHARMACOL,MIAMI,FL 33101
[3] HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115
来源：
FEBS LETTERS | 1992年 / 299卷 / 01期
关键词：
TRIADIN; EXCITATION-CONTRACTION COUPLING; CA2+ RELEASE; SARCOPLASMIC RETICULUM;
D O I：
10.1016/0014-5793(92)80100-U
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The monoclonal antibody, mAb GE 4.90, raised against triadin, a 95 kDa protein of sarcoplasmic reticulum (SR), inhibits the slow phase of Ca2+ release from SR following depolarization of the T-tubule moiety of the triad. The antibody has virtually no effect on the fast phase of depolarization-induced Ca2+ release nor on caffeine-induced Ca2+ release. Since the slow phase of depolarization-induced Ca2+ release is also inhibited by dihydropyridines (DHP), these results suggest that triadin may be involved in the functional coupling between the DHP receptor and the SR Ca2+ channel.
引用
收藏
页码：57 / 59
页数：3
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