EFFECTS OF ANTI-TRIADIN ANTIBODY ON CA2+ RELEASE FROM SARCOPLASMIC-RETICULUM

被引：44

作者：

BRANDT, NR

CASWELL, AH

BRUNSCHWIG, JP

KANG, JJ

ANTONIU, B

IKEMOTO, N

机构：

[1] BOSTON BIOMED RES INST,DEPT MUSCLE RES,BOSTON,MA 02114

[2] UNIV MIAMI,SCH MED,DEPT PHARMACOL,MIAMI,FL 33101

[3] HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115

来源：

FEBS LETTERS | 1992年 / 299卷 / 01期

关键词：

TRIADIN; EXCITATION-CONTRACTION COUPLING; CA2+ RELEASE; SARCOPLASMIC RETICULUM;

D O I：

10.1016/0014-5793(92)80100-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The monoclonal antibody, mAb GE 4.90, raised against triadin, a 95 kDa protein of sarcoplasmic reticulum (SR), inhibits the slow phase of Ca2+ release from SR following depolarization of the T-tubule moiety of the triad. The antibody has virtually no effect on the fast phase of depolarization-induced Ca2+ release nor on caffeine-induced Ca2+ release. Since the slow phase of depolarization-induced Ca2+ release is also inhibited by dihydropyridines (DHP), these results suggest that triadin may be involved in the functional coupling between the DHP receptor and the SR Ca2+ channel.

引用

页码：57 / 59

页数：3

共 21 条

[1] STRUCTURAL EVIDENCE FOR DIRECT INTERACTION BETWEEN THE MOLECULAR-COMPONENTS OF THE TRANSVERSE TUBULE SARCOPLASMIC-RETICULUM JUNCTION IN SKELETAL-MUSCLE [J].