GAMMA-AMINOBUTYRIC-ACID (GABA-B) RECEPTOR-MEDIATED INHIBITION OF TYROSINE-HYDROXYLASE ACTIVITY IN THE STRIATUM OF RAT

被引：18

作者：

ARIASMONTANO, JA ^{[1
]}

MARTINEZFONG, D ^{[1
]}

ACEVES, J ^{[1
]}

机构：

[1] NATL POLYTECH INST,CTR INVEST & ESTUDIOS AVANZADOS,DEPT FISIOL BIOFIS & NEUROCIENCIAS,MEXICO CITY 14,DF,MEXICO

来源：

NEUROPHARMACOLOGY | 1991年 / 30卷 / 10期

关键词：

TYROSINE HYDROXYLASE; BACLOFEN; GABA-B RECEPTORS; NEOSTRIATUM; DOPAMINE SYNTHESIS; NIGROSTRIATAL PATHWAY;

D O I：

10.1016/0028-3908(91)90132-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of GABA and GABA agonists on calcium and depolarization-dependent stimulation of tyrosine hydroxylase activity in striatal slices were studied. Gamma-Aminobutyric acid and (-)baclofen inhibited, while muscimol and (+)baclofen did not affect, the stimulation of tyrosine hydroxylase. The inhibitory effect of GABA and (-)baclofen was blocked by the GABA(B) antagonist, phaclofen but not by the GABA(A) antagonist, picrotoxin. The data suggest that the activity of tyrosine hydroxylase on dopaminergic nigrostriatal terminals may be modulated by GABA via GABA(B) receptors.

引用

收藏

页码：1047 / 1051

页数：5

相关论文

共 26 条

[1]

ANTON AH, 1962, J PHARMACOL EXP THER, V138, P360

[2] EFFECT OF VARIOUS DECARBOXYLASE INHIBITORS ON CEREBRAL METABOLISM OF DIHYDROXYPHENYLALANINE [J].

BARTHOLINI, G ;

PLETSCHER, A .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1969, 21 (05) :323-+

[3] A TYPE OF ASPINY NEURON IN THE RAT NEOSTRIATUM ACCUMULATES [H-3]GAMMA-AMINOBUTYRIC ACID - COMBINATION OF GOLGI-STAINING, AUTORADIOGRAPHY, AND ELECTRON-MICROSCOPY [J].

BOLAM, JP ;

CLARKE, DJ ;

SMITH, AD ;

SOMOGYI, P .

JOURNAL OF COMPARATIVE NEUROLOGY, 1983, 213 (02) :121-134

[4] GLUTAMATE DECARBOXYLASE-IMMUNOREACTIVE STRUCTURES IN THE RAT NEOSTRIATUM - A CORRELATED LIGHT AND ELECTRON-MICROSCOPIC STUDY INCLUDING A COMBINATION OF GOLGI IMPREGNATION WITH IMMUNOCYTOCHEMISTRY [J].

BOLAM, JP ;

POWELL, JF ;

WU, JY ;

SMITH, AD .

JOURNAL OF COMPARATIVE NEUROLOGY, 1985, 237 (01) :1-20

[5]

BOWERY N G, 1986, British Journal of Pharmacology, V87, p37P

[6] (-) BACLOFEN DECREASES NEUROTRANSMITTER RELEASE IN THE MAMMALIAN CNS BY AN ACTION AT A NOVEL GABA RECEPTOR [J].

BOWERY, NG ;

HILL, DR ;

HUDSON, AL ;

DOBLE, A ;

MIDDLEMISS, DN ;

SHAW, J ;

TURNBULL, M .

NATURE, 1980, 283 (5742) :92-94

[7] PRESYNAPTIC REGULATION OF NEUROTRANSMITTER RELEASE IN THE BRAIN - FACTS AND HYPOTHESIS [J].

CHESSELET, MF .

NEUROSCIENCE, 1984, 12 (02) :347-375

[8] INHIBITION OF CALCIUM CURRENTS IN CULTURED RAT DORSAL-ROOT GANGLION NEURONS BY (-)-BACLOFEN [J].

DOLPHIN, AC ;

SCOTT, RH .

BRITISH JOURNAL OF PHARMACOLOGY, 1986, 88 (01) :213-220

[9] NEUROTRANSMITTERS DECREASE THE CALCIUM CONDUCTANCE ACTIVATED BY DEPOLARIZATION OF EMBRYONIC CHICK SENSORY NEURONS [J].

DUNLAP, K ;

FISCHBACH, GD .

JOURNAL OF PHYSIOLOGY-LONDON, 1981, 317 (AUG) :519-535

[10] TYROSINE-HYDROXYLASE ACTIVATION IN DEPOLARIZED DOPAMINERGIC TERMINALS - INVOLVEMENT OF CA-2+-DEPENDENT PHOSPHORYLATION [J].

ELMESTIKAWY, S ;

GLOWINSKI, J ;

HAMON, M .

NATURE, 1983, 302 (5911) :830-832