EFFECT OF SEROTONIN ON CYCLIC-AMP LEVEL IN RAT HYPOTHALAMUS SLICES DURING DEVELOPMENT

被引：6
作者：
DASZUTA, A
PONS, F
CADILHAC, J
机构：
[1] INSERM, RECH NEUROBIOL UNITE, F-13009 MARSEILLE, FRANCE
[2] FAC MED MONTPELLIER, PATHOL & THERAPEUT GEN LAB, F-34000 MONTPELLIER, FRANCE
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 56卷 / 04期
关键词：
Cyclic AMP; Hypothalamus; Ontogenesis; Serotonin;
D O I：
10.1016/0014-2999(79)90271-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of serotonin (5-HT [hydroxytryptamine]) on cyclic[c]AMP levels in rat hypothalamic slices was age-dependent. The sensitivity of the cAMP system to 5 .times. 10-5 M 5-HT already existed in the fetus at 21 days of pregnancy. It reached a maximum on the 7th postnatal day and then decreased with age. In adult tissue the response was still present and was antagonized by 2 serotonergic antagonists (methiothepin and metergoline). When compared to the progressive increase of 5-HT level in the hypothalamus the data suggest a different development of serotonergic innervation and of 5-HT receptors.
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收藏
页码：397 / 401
页数：5
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