ISOLATION AND PRIMARY STRUCTURE OF ENDORPHIN FROM SALMON PITUITARY-GLANDS

被引：43

作者：

KAWAUCHI, H ^{[1
]}

TUBOKAWA, M ^{[1
]}

MURAMOTO, K ^{[1
]}

机构：

[1] TOHOKU UNIV, FAC AGR, ANALYT CHEM LAB, SENDAI, MIYAGI 980, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)91114-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endorphin has been isolated from an acid acetone extract of the pituitary of the salmon Oncorhynchus keta by ion exchange chromatography and gel filtration. Sequence analysis revealed it to be a nonacosapeptide with following primary structure: Ac-Tyr-Gly-Gly-Phe-Met-Lys-Pro-Tyr-Thr-Lys-Gln-Ser-His-Lys-Pro-Leu-Ile-Thr-Leu-Leu-Lys-His- Ile-Thr-Leu-Lys-Asn-Glu-Gln-OH. It appears that the amino terminal segment which is necessary for analgesic activity is conserved through the evolution of vertebrate except for the blocking of the amino terminal of salmon endorphin. © 1979.

引用

页码：1249 / 1254

页数：6

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