AMPK in regulation of apical junctions and barrier function of intestinal epithelium

被引：57

作者：

Zhu, Mei-Jun ^{[1
]}

Sun, Xiaofei ^{[1
]}

Du, Min ^{[2
]}

机构：

[1] Washington State Univ, Sch Food Sci, Pullman, WA 99164 USA

[2] Washington State Univ, Dept Anim Sci, Pullman, WA 99164 USA

来源：

TISSUE BARRIERS | 2018年 / 6卷 / 02期

基金：

美国国家卫生研究院; 美国食品与农业研究所;

关键词：

adherens junction; AMPK; barrier function; epithelial differentiation; tight junction;

D O I：

10.1080/21688370.2018.1487249

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Gut epithelium covers the inner layer of the gastrointestinal tract and provides a physical barrier to separate the host from its external environment, and its barrier function is critical for maintaining host health. AMP-activated protein kinase (AMPK) as a master regulator of energy metabolism plays a critical role in epithelial barrier function. AMPK activation promotes epithelial differentiation and facilitates cell polarity establishment, both of which strengthen epithelial barrier. In addition, AMPK promotes the assembly of tight junctions and adherens junctions by direct phosphorylation of proteins composing apical junctions, junctional anchors, and cytoskeletons. Pharmacological and nutraceutical compounds, as well as physiological states triggering AMPK activation strengthen epithelial barrier function. This review summarized recent progress in delineating the regulatory roles of AMPK in apical junction formation and barrier function of intestinal epithelium.

引用

页码：1 / 13

页数：13

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