Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed

被引:631
作者
不详
机构
关键词
Mycotoxins; Fusarium; HT-2; toxin; T-2; food; feed; analysis; occurrence; human dietary exposure; animal dietary exposure; risk assessment; toxicity; tolerable daily intake (TDI);
D O I
10.2903/j.efsa.2011.2481
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
T-2 toxin and HT-2 toxin are mycotoxins produced by various Fusarium species. The European Commission asked EFSA for a scientific opinion on the risk to human and animal health related to the presence of T-2 and HT-2 toxin in food and feed. A total of 20,519 results for the sum of T-2 and HT-2 toxins in food, feed and unprocessed grains, collected in 2005-2010 from 22 European countries, were used in the evaluation. The highest mean concentrations for the sum of T-2 and HT-2 toxins were observed in grains and grain milling products, notably in oats and oat products. Grains and grain-based foods, in particular bread, fine bakery wares, grain milling products, and breakfast cereals, made the largest contribution to the sum of T-2 and HT-2 toxin exposure for humans. T-2 toxin is rapidly metabolised to a large number of products, HT-2 toxin being a major metabolite. Pigs are amongst the most sensitive animals towards the effects of T-2 toxin, the most sensitive endpoints being immunological or haematological effects. Using these data and a benchmark dose analysis the Panel on Contaminants in the Food Chain established a group tolerable daily intake (TDI) of 100 ng/kg b.w. for the sum of T-2 and HT-2 toxins. Estimates of chronic human dietary exposure to the sum of T-2 and HT-2 toxins based on the available occurrence data are below the TDI for populations of all age groups, and thus not a health concern. For ruminants, rabbits and farmed fish the estimated exposures to the sum of these toxins based on the available occurrence data are considered unlikely to be a health concern, while for pigs, poultry, dogs and horses the risk of adverse health effects is low. For cats the health risk from the exposure to T-2 and HT-2 toxins cannot be assessed. (C) European Food Safety Authority, 2011
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页数:187
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共 363 条
  • [1] AFRC, 1993, ENERGY PROTEIN REQUI
  • [2] AFSSA, 2009, EV RISQ LIES PRES MY
  • [3] Ahmadi Kazem, 2008, Iran J Immunol, V5, P177, DOI IJIv5i3A6
  • [4] T-2 toxin-induced apoptosis in rat keratinocyte primary cultures
    Albarenque, SM
    Doi, K
    [J]. EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2005, 78 (02) : 144 - 149
  • [5] Kinetics of cytokines mRNAs expression in the dorsal skin of WBN/ILA-Ht rats following topical application of T-2 toxin
    Albarenque, SM
    Suzuki, K
    Nakayama, H
    Doi, K
    [J]. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2001, 53 (04) : 271 - 274
  • [6] Albarenque SM, 2001, EXP TOXICOL PATHOL, V52, P553, DOI 10.1016/S0940-2993(01)80016-6
  • [7] Albarenque SM, 1999, HISTOL HISTOPATHOL, V14, P337, DOI 10.14670/HH-14.337
  • [8] Albarenque SM, 2000, EXP TOXICOL PATHOL, V52, P297
  • [9] Impaired semen quality of AI bulls fed with moldy hay:: a case report
    Alm, K
    Dahlbom, M
    Säynäjärvi, M
    Andersson, MA
    Salkinoja-Salonen, MS
    Andersson, MC
    [J]. THERIOGENOLOGY, 2002, 58 (08) : 1497 - 1502