Electroacupuncture at Zusanli Rescues the Enteric Neuronal Loss in the Stomach of Diabetic Rats

被引：2

作者：

Hu, Min ^{[1
]}

Du, Fan ^{[1
]}

Liu, Shi ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Wuhan, Hubei, Peoples R China

来源：

JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE | 2013年 / 18卷 / 01期

基金：

中国国家自然科学基金;

关键词：

diabetes; enteric nervous system; enteric neurons; electroacupuncture;

D O I：

10.1177/2156587212455646

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The purpose of this study was to investigate the effects of electroacupuncture at Zusanli acupoint on the enteric neuropathy in diabetic rats. Sprague-Dawley rats were divided into different groups depending on the total electroacupuncture span and frequency. The expression of nitric oxide synthase (nNOS), choline acetyltransferase (CHAT), protein gene product 9.5 (PGP9.5), and doublecortin was significantly decreased in the diabetic group compared with the control group. Long-term electroacupuncture at Zusanli with either high frequency or low frequency could increase the expression levels of nNOS, CHAT, PGP9.5, and doublecortin, and the increase was greater in the high-frequency group. But no obvious changes were seen in the short-term electroacupuncture groups. These results suggest that electroacupuncture at Zusanli can restore the deficiency of enteric neurons in diabetes partly but a comparative long duration of stimuli (6 weeks) is required. The increase of doublecortin may be involved in this positive process.

引用

页码：5 / 14

页数：10

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