Biological subtypes of breast cancer: Prognostic and therapeutic implications

被引：756

作者：

Yersal, Ozlem ^{[1
]}

Barutca, Sabri ^{[1
]}

机构：

[1] Adnan Menderes Univ, Med Fac, Dept Internal Med, Div Med Oncol, TR-09010 Aydin, Turkey

来源：

WORLD JOURNAL OF CLINICAL ONCOLOGY | 2014年 / 5卷 / 03期

关键词：

Breast cancer; Tumor biology; Subtypes; Predictive factors; Prognostic factors;

D O I：

10.5306/wjco.v5.i3.412

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is a heterogeneous complex of diseases, a spectrum of many subtypes with distinct biological features that lead to differences in response patterns to various treatment modalities and clinical outcomes. Traditional classification systems regarding biological characteristics may have limitations for patient-tailored treatment strategies. Tumors with similar clinical and pathological presentations may have different behaviors. Analyses of breast cancer with new molecular techniques now hold promise for the development of more accurate tests for the prediction of recurrence. Gene signatures have been developed as predictors of response to therapy and protein gene products that have direct roles in driving the biology and clinical behavior of cancer cells are potential targets for the development of novel therapeutics. The present review summarizes current knowledge in breast cancer molecular biology, focusing on novel prognostic and predictive factors. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：412 / 424

页数：13

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