ABSORPTION OF RADIOLABELED SOLUBLE INSULIN IN TYPE-1 (INSULIN-DEPENDENT) DIABETES - INFLUENCE OF SUBCUTANEOUS BLOOD-FLOW AND ANTHROPOMETRY

被引：24

作者：

VORA, JP

BURCH, A

PETERS, JR

OWENS, DR

机构：

[1] Departments of Medicine, University of Wales College of Medicine, Cardiff, Heath Park

[2] Departments of Medical Physics, University of Wales College of Medicine, Cardiff, Heath Park

来源：

DIABETIC MEDICINE | 1993年 / 10卷 / 08期

关键词：

TYPE-1 (INSULIN-DEPENDENT) DIABETES; SOLUBLE INSULIN ABSORPTION; SUBCUTANEOUS BLOOD FLOW; ANTHROPOMETRY;

D O I：

10.1111/j.1464-5491.1993.tb00157.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The rate of absorption of soluble insulin, and its relationships with subcutaneous blood flow (SCBF) and patients' anthropometry, were investigated in 12 male Type 1 (insulin-dependent) diabetic patients of less than 10 yr disease duration (age range: 23-29 yr; body mass index (BMI): 22.2-30.8 kg m-2). Simultaneous assessment of the absorption of I-125-labelled soluble insulin and SCBF (Technetium-99m clearance) were performed, on separate study days, for the anterior abdominal wall, anterior mid-thigh, and the upper arm injection sites. Absorption of I-125 soluble insulin, including during the lag-phase, was determined by the two- and three-parameters biexponential models description of residual radioactivity levels at the injection site. Anthropometric measurements utilized were: BMI, ultrasonic measurement of the subcutaneous adipose tissue layer, and caliper skinfold thickness at anterior abdominal wall, biceps, triceps, anterior mid-thigh and subscapular sites. Rate-constants for absorption of soluble insulin were positively correlated with SCBF (Spearman rank coefficient (r(s)) = 0.33-0.55; p < 0.01-0.001). An inverse relationship was observed between the duration of the lag-phase and SCBF (r(s) = -0.28-0.54; p < 0.05-0.001). Patients' degree of adiposity was inversely correlated with the rate of soluble insulin absorption (r(s) = -0.24-0.28; p < 0.05) and SCBF (r(s) = -0.28-0.43; p < 0.05-0.001). Consequently, faster absorption of soluble insulin, with shorter lag-phase duration, was noted for the abdominal and thigh sites for non-obese (BMI > 25 kg m-2) than obese patients (BMI < 27.5 kg m-2) (p < 0.05-0.01). In Type 1 (insulin-dependent) diabetic patients, the rate of absorption of soluble insulin, including during the lag-phase, is positively correlated with subcutaneous blood flow. Increasing adiposity prolongs the duration of the early lag-phase and reduces the rate of absorption of soluble insulin and subcutaneous blood flow.

引用

页码：736 / 743

页数：8

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