CALCIUM-REGULATING HORMONES AND BONE-MINERAL CONTENT IN PATIENTS AFTER SUBTOTAL GASTRECTOMY

被引：18

作者：

KOBAYASHI, S

TAKAHASHI, C

KURODA, T

SUGENOYA, A

IIDA, F

KATOH, K

机构：

[1] The Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, 390

[2] Department of Surgery, Kufu City Hospital, Kofu, 400

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1994年 / 24卷 / 04期

关键词：

PARATHYROID HORMONE; CALCITONIN; VITAMIN-D; GASTRECTOMY; BONE MINERAL CONTENT;

D O I：

10.1007/BF02348555

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Twenty-nine men who had undergone Billroth I gastrectomy and 19 men who had undergone Billroth II gastrectomy were studied to examine the changes in their calcium regulating hormones and bone mineral content following surgery. The serum calcium and phosphate concentrations in the patients with Billroth I and Billroth II were normal. The Billroth II group and had an elevated level of serum alkaline phosphatase and reduced bone mineral content. The 24,25(OH)2D concentration was reduced (P < 0.01) and 25(OH)D and 1,25(OH)2D concentrations were increased (P < 0.01, P < 0.05, respectively) in the Billroth II group. It was suggested by our study that the Billroth II patients had a reduced bone mineral content and an elevated 1,25(OH)2D concentration. Therefore, the pathophysiology of postgastrectomy bone metabolic disease is not due to vitamin D deficiency, but may instead be due to reduced calcium absorption in the intestine.

引用

页码：295 / 298

页数：4

共 20 条

[1]

Sarasin V.C., Osteomalacie und hypochrome Anemie nach Magenresektion, Gastroenterologia, 66, pp. 734-738, (1941)

[2]

Eddy R.L., Metabolic bone disease after gastrectomy, Am J Med, 50, pp. 442-449, (1971)

[3]

Tougaard L., Bone composition and vitamin D after Polya gastrectomy, Acta Med Scand, 202, pp. 47-50, (1977)

[4]

Duncombe U.M., Reeve J., Calcium homeostasis in digestive disorders, Clin Gastroenterol, 65, pp. 653-670, (1981)

[5]

Fukuda M., Hirota M., Sato S., Bone lesions and dental caries after gastrectomy — Evaluation of milk intolerance and operative procedure, Jpn J Surg, 16, pp. 36-41, (1986)

[6]

Arnaud C.D., Goldsmith R.S., Bordier D.J., Sizemore G.W., Influence of immunoheterogeneity of circulating parathyroid hormone on results of radioimmunoassays of serum in man, Am J Med, 56, pp. 785-793, (1974)

[7]

Shepard R.M., Determination of vitamin D and its metabolites in plasma from normal and anephric man, Biochem J, 182, pp. 55-69, (1979)

[8]

Inoue T., Kusida K., Miyamoto S., Sumi Y., Quantitative assessment of bone density on X-ray picture, J Jpn Orthop Assn, 57, pp. 1923-1936, (1983)

[9]

Imawari M., Kozawa K., Akanuma Y., Koizumi S., Itakura H., Kosaka K., Serum 25-hydroxyvitamin D and vitamin D binding protein levels and mineral metabolism after partial gastrectomy, Gastroenterology, 79, pp. 255-258, (1980)

[10]

Gacs G., Barltrop D., Significance on Ca-soap formation for calcium absorption in the rat, Gut, 18, pp. 64-68, (1977)

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