INDUCTION OF ORAL TOLERANCE AFTER FEEDING OF RAGWEED PELLET EXTRACT IN MICE

The induction of oral tolerance following the feeding of ragweed pollen and its extract was investigated in BALB/c mice. Antibody class-specific immune suppression could be observed, and the IgE response was specifically suppressed, depending on the amount of ragweed pollen extract fed when subsequently immunized with ragweed extract together with A1(OH)(3) as an adjuvant. A multiple feeding was more effective than a single feeding of antigen, and the IgE response was completely suppressed when 20 mg of pollen extract was fed for 5 consecutive days. On the other hand, IgG production was not suppressed even though a large amount of ragweed pollen or its extract was fed. Furthermore, no secretion of antigen-specific IEA into saliva was observed in control animals or those fed ragweed pollen extract. Thus, pollen extract feeding may be potentially useful for the prophylaxis or therapy of allergic rhinitis induced by ragweed.