THE BACTERICIDAL ACTIVITY OF SPARFLOXACIN

被引：22

作者：

LEWIN, CS ^{[1
]}

MORRISSEY, I ^{[1
]}

SMITH, JT ^{[1
]}

机构：

[1] UNIV LONDON,SCH PHARM,DEPT PHARMACEUT,MICROBIOL SECT,LONDON WC1N 1AX,ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1992年 / 30卷 / 05期

关键词：

D O I：

10.1093/jac/30.5.625

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Sparfloxacin was found to display a biphasic response against Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis in nutrient broth. Its optimum bactericidal concentration was found to be identical for all three species which contrasts with other clinically available fluoroquinolones that are more active against E. coli than against staphylococci. Bacterial protein and RNA synthesis as well as cell division were not found to be essential for all the lethality of sparfloxacin, which hence displays bactericidal mechanism B. However, sparfloxacin was unable to kill bacteria in absence of oxygen. © 1992 The British Society for Antimicrobial Chemotherapy.

引用

页码：625 / 632

页数：8

共 21 条

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