STEREOSELECTIVE SYNTHESIS OF 4'-C-BRANCHED 2',3'-DIDEHYDRO-2',3'-DIDEOXY NUCLEOSIDES BASED ON SNCL4-PROMOTED ALLYLIC REARRANGEMENT

被引：20

作者：

HARAGUCHI, K ^{[1
]}

TANAKA, H ^{[1
]}

ITOH, Y ^{[1
]}

SAITO, S ^{[1
]}

MIYASAKA, T ^{[1
]}

机构：

[1] SHOWA UNIV,SCH PHARMACEUT SCI,HATANODAI 1-5-8,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 20期

关键词：

3'; 4'-UNSATURATED URACIL NUCLEOSIDE; ALLYLIC REARRANGEMENT; ORGANOSILICON REAGENT; 2'; 3'-DIDEHYDRO-2'; 3'-DIDEOXYURIDINE; 4'-C-BRANCHED NUCLEOSIDE;

D O I：

10.1016/S0040-4039(00)78874-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based on SnCl4-promoted allylic rearrangement between a 3',4'-unsaturated uracil nucleoside and organosilicon reagents, stereoselective introduction of carbon functionalities to the 4'-position has been accomplished, disclosing a new entry for a series of 4'-C-branched nucleosides of biological interests.

引用

页码：2841 / 2844

页数：4

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