STEREOSELECTIVE SYNTHESIS OF 4'-C-BRANCHED 2',3'-DIDEHYDRO-2',3'-DIDEOXY NUCLEOSIDES BASED ON SNCL4-PROMOTED ALLYLIC REARRANGEMENT

被引：20
|
作者：
HARAGUCHI, K [1 ]
TANAKA, H [1 ]
ITOH, Y [1 ]
SAITO, S [1 ]
MIYASAKA, T [1 ]
机构：
[1] SHOWA UNIV,SCH PHARMACEUT SCI,HATANODAI 1-5-8,SHINAGAWA KU,TOKYO 142,JAPAN
来源：
TETRAHEDRON LETTERS | 1992年 / 33卷 / 20期
关键词：
3'; 4'-UNSATURATED URACIL NUCLEOSIDE; ALLYLIC REARRANGEMENT; ORGANOSILICON REAGENT; 2'; 3'-DIDEHYDRO-2'; 3'-DIDEOXYURIDINE; 4'-C-BRANCHED NUCLEOSIDE;
D O I：
10.1016/S0040-4039(00)78874-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Based on SnCl4-promoted allylic rearrangement between a 3',4'-unsaturated uracil nucleoside and organosilicon reagents, stereoselective introduction of carbon functionalities to the 4'-position has been accomplished, disclosing a new entry for a series of 4'-C-branched nucleosides of biological interests.
引用
收藏
页码：2841 / 2844
页数：4
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