Role of angiogenesis in urothelial bladder carcinoma

被引：48
作者：
Fus, Lukasz Piotr [1 ]
Gornicka, Barbara [1 ]
机构：
[1] Med Univ Warsaw, Dept Pathol, 7 Pawinskiego St, PL-02106 Warsaw, Poland
来源：
Central European Journal of Urology | 2016年 / 69卷 / 03期
关键词：
urothelial carcinoma; bladder cancer; angiogenesis; angiogenic factors; biomarkers; cancer stem cells;
D O I：
10.5173/ceju.2016.830
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction Bladder cancer is the most common urinary tract malignancy in western countries. In recent years, extensive research has suggested that angiogenesis plays an important role in bladder cancer biology, contributing to tumor growth and progression. Material and methods In this review, we discuss general mechanisms of angiogenesis and highlight the influence of pro-and anti-angiogenic factors, and cancer stem cells on bladder cancer biology, their relation to disease progression, and potential use in novel targeted therapies. Results Expression of a number of proangiogenic factors, including HIF-1, VEGF, bFGF, IL-8 and MMPs, as well as anti-angiogenic factor TSP-1, was found to be altered in bladder tumors. Involvement of cancer stem cells in bladder cancer development was also proposed. Conclusions High expression of most pro-angiogenic factors correlated with disease progression and shorter patient survival, but discrepancies between studies urge us to continue evaluating the significance of angiogenesis in bladder cancer.
引用
收藏
页码：258 / 263
页数：6
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