EFFECT OF 1-BETA-D-ARABINOFURANOSYLTHYMINE ON THE GROWTH OF HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2

被引：5

作者：

FALKE, D ^{[1
]}

MOSER, H ^{[1
]}

LINK, D ^{[1
]}

MULLER, WEG ^{[1
]}

机构：

[1] UNIV MAINZ,INST PHYSIOL CHEM,D-6500 MAINZ,FED REP GER

来源：

JOURNAL OF GENERAL VIROLOGY | 1979年 / 42卷 / FEB期

关键词：

D O I：

10.1099/0022-1317-42-2-435

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The influence of araT on the synthesis of HSV of types 1 and 2 including a TK(-)variant, on the activity of the dThd and the dCyd kinases and on the incorporation of radioactivity into insoluble or soluble material after infection was studied. AraT inhibited different parameters of the replication of a TK(-)variant; it is possibly phosphorylated by enzymes other than the deoxypyrimidine kinase and therefore it is less selectively phosphorylated than dThd. The mode of action of araT on herpes replication must be studied in more detail.

引用

页码：435 / 438

页数：4

共 13 条

[1] ANTIVIRAL ACTIVITY OF ARABINOSYLTHYMINE IN HERPESVIRAL REPLICATION - MECHANISM OF ACTION INVIVO AND INVITRO
ASWELL, JF
ALLEN, GP
JAMIESON, AT
CAMPBELL, DE
GENTRY, GA
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 12 (02) : 243 - 254
[2] UPTAKE OF [H-3] THYMIDINE AND CELL DNA-SYNTHESIS DURING EARLY MULTIPLICATION PHASE OF HERPESVIRUS HOMINIS IN BHK CELLS
BITTLINGMAIER, K
SCHNEIDER, D
FALKE, D
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 407 (04) : 384 - 391
[3] THYMIDINE TRANSPORT IN HERPESVIRUS HOMINIS TYPE-1 AND TYPE-2 INFECTED BHK 21 CELLS
BITTLINGMAIER, K
SCHNEIDER, D
FALKE, D
[J]. JOURNAL OF GENERAL VIROLOGY, 1977, 35 (APR) : 159 - 173
[4] DERUDDER J, 1965, ANTIMICROBIAL AGENTS, V259, P578
[5] ENZYMATIC BASIS FOR SELECTIVE-INHIBITION OF VARICELLA-ZOSTER VIRUS BY 5-HALOGENATED ANALOGS OF DEOXYCYTIDINE
DOBERSEN, MJ
JERKOFSKY, M
GREER, S
[J]. JOURNAL OF VIROLOGY, 1976, 20 (02) : 478 - 486
[6] THYMIDINE-KINASE, URIDINE-KINASE AND CHOLINE-KINASE IN RABBIT KIDNEY-CELLS INFECTED WITH HERPESVIRUS HOMINIS, TYPE I AND II
DUNDAROFF, S
FALKE, D
[J]. ARCHIV FUR DIE GESAMTE VIRUSFORSCHUNG, 1972, 38 (01): : 56 - +
[7] INFLUENCE OF DOUBLE INFECTIONS ON INDUCTION OF THYMIDINE KINASE BY UV-IRRADIATED HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2 AND PSEUDORABIES VIRUS
DUNDAROFF, S
JUST, I
FALKE, D
[J]. ARCHIVES OF VIROLOGY, 1975, 49 (2-3) : 117 - 126
[8] INHIBITION OF HERPES-SIMPLEX VIRUS REPLICATION BY ARAT
GENTRY, GA
ASWELL, JF
[J]. VIROLOGY, 1975, 65 (01) : 294 - 296
[9] BIOCHEMICAL STUDIES ON HERPES-SIMPLEX VIRUS-SPECIFIED DEOXYPYRIMIDINE KINASE-ACTIVITY
JAMIESON, AT
SUBAKSHA.JH
[J]. JOURNAL OF GENERAL VIROLOGY, 1974, 24 (SEP) : 481 - 492
[10] REGULATION BY THYMIDINE MONOPHOSPHATE AND OTHER NUCLEOTIDES OF THYMIDINE KINASE-ACTIVITY IN EXTRACTS FROM PRIMARY RABBIT KIDNEY-CELLS INFECTED BY HSV TYPES-1 AND 2
JUST, I
DUNDAROFF, S
FALKE, D
WOLF, HU
[J]. JOURNAL OF GENERAL VIROLOGY, 1975, 29 (OCT) : 69 - 80

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