LFA-3, CD44, AND CD45 - PHYSIOLOGICAL TRIGGERS OF HUMAN MONOCYTE TNF AND IL-1 RELEASE

被引：316
|
作者：
WEBB, DSA
SHIMIZU, Y
VANSEVENTER, GA
SHAW, S
GERRARD, TL
机构：
[1] US FDA, CTR BIOL EVALUAT & RES, DIV CYTOKINE BIOL, BETHESDA, MD 20892 USA
[2] NCI, EXPTL IMMUNOL BRANCH, BETHESDA, MD 20892 USA
来源：
SCIENCE | 1990年 / 249卷 / 4974期
关键词：
D O I：
10.1126/science.1697984
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The monocyte-derived cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), are central regulators ofthe immune response, but the physiologic stimuli for their release remain lagely undefined. Engagement of three monocyte glycoproteins, LFA-3, CD44, and CD45, by specific monoclonal antibodies immobilized on plastic induced TNF-α and IL-1β release. In addition, TNF-α was released when monocyte LFA-3 bound immobilized, purified CD2, which is its physiologic receptor. Thus, a receptor-ligand interaction that mediates cell-cell adhesion can transmit the necessary signals for the release of monokines.
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页码：1295 / 1297
页数：3
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