Facile synthesis of some novel 2-substituted-4,6-diarylpyrimidines using 4 '-hydroxy-3 ', 5 '-dinitrochalcones and S-benzylthiouronium chloride

Various 4'-hydroxy-3', 5'-dinitro substituted chalcones 1 and S-benzylthiouronium chloride (SBT) 2 in the presence of DMF-organic bases (morpholine/pyrrolidine/piperidine) gave 4,6-diaryl-2-(4-morpholinyl/1-pyrrolidinyl/1-piperidinyl)-pyrimidines 4, 5 and 6 in a facile one-pot conversion. In an another attempt reactants 1 and 2 yielded intermediate 2-benzylthiopyrimidines 3, in presence of DMF, which on treatment with heterocyclic secondary amines gave products 4, 5 and 6 in an alternate two-step process.