Influence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus

被引：26
作者：
Chan, SH
Thai, AC
Lin, YN
Liu, KF
Wee, GB
机构：
[1] NATL UNIV SINGAPORE,FAC MED,DEPT MICROBIOL,SINGAPORE 0511,SINGAPORE
[2] NATL UNIV SINGAPORE,FAC MED,DEPT MED,SINGAPORE 0511,SINGAPORE
来源：
HUMAN IMMUNOLOGY | 1995年 / 44卷 / 03期
关键词：
D O I：
10.1016/0198-8859(95)00085-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IDDM in Singaporean Chinese was associated with HLA B58, DRB1*0301, DQB1*0201, and joint occurrences of DRB1*0301/*0901 and DRB1*0301/*04. Of the DR4s the frequencies of DRB1*0401, *0404, and *0405 were higher and *0406 was lower in patients compared to controls. DRB1*0301/*0901 was observed mainly in female patients and the frequency showed an inverse relationship with age at onset, whereas DRB1*0301/*04 was observed mainly in male patients and also showed an inverse relationship with age at onset. DRB1*1202 showed an increasing frequency with age at onset. IDDM patients had a higher frequency of homozygous NAsp57 DQ beta chains and a lower frequency of homozygous Asp57 DQ beta chains compared to controls, especially in younger onset patients.
引用
收藏
页码：175 / 180
页数：6
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