L-CARNITINE EFFECTS ON ANEMIA IN HEMODIALYZED PATIENTS TREATED WITH ERYTHROPOIETIN

被引:135
作者
LABONIA, WD [1 ]
机构
[1] SANATORIO GUEMES HOSP PRIVADO, SERV NEFROL, BUENOS AIRES, DF, ARGENTINA
关键词
L-CARNITINE; ANEMIA; HEMODIALYSIS; ERYTHROPOIETIN;
D O I
10.1016/0272-6386(95)90439-5
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
To demonstrate whether L-carnitine treatment could further improve the anemia in dialyzed patients under recombinant human erythropoietin (r-HuEPO) therapy, leading to a reduction in r-HuEPO requirements, L-carnitine (1 g intravenously after every dialysis session) was administered for 6 months to a group of 13 patients; the results were compared with data from a placebo control group (N = 11), Globular osmotic fragility and endogenous EPO secretion were also evaluated. L-Carnitine treatment promoted a 38.1% reduction in r-HuEPO requirements in the active group (102.2 +/- 52.6 U/kg/wk v 63.3 +/- 37.8 U/kg/wk; P < 0.02), with globular osmotic fragility and endogenous EPO levels remaining unchanged and thus not accounting for carnitine effect on anemia, In the active group, seven patients decreased r-HuEPO needs (responders), while six did not (nonresponders), Compared with nonresponders, responders showed higher mean values at time 0 for r-HuEPO requirements and endogenous plasma EPO levels, although not statistically significant, It is concluded that L-carnitine deficiency might promote EPO resistance in dialyzed patients, which is corrected by L-carnitine supplementation, ultimately reducing r-HuEPO requirements. (C) 1995 by the National Kidney Foundation, Inc.
引用
收藏
页码:757 / 764
页数:8
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