ABSENCE OF EXPRESSION OF INTERLEUKIN-6 (IL-6) MESSENGER-RNA IN REGENERATING RAT-LIVER

被引：13
作者：
SCOTTE, M [1 ]
DAVEAU, M [1 ]
HIRON, M [1 ]
TENIERE, P [1 ]
LEBRETON, JP [1 ]
机构：
[1] INSERM,UNITE 78,BP 73,F-76233 BOIS GUILLAUME,FRANCE
来源：
FEBS LETTERS | 1993年 / 315卷 / 02期
关键词：
INTERLEUKIN-6; HEPATIC REGENERATION; RAT;
D O I：
10.1016/0014-5793(93)81154-R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The serum level of IL-6 and expression of IL-6 mRNA in hepatocytes from regenerating liver were investigated in the rat. The IL-6 level in the serum was not significantly different from that of a control group of rats submitted to an acute experimental inflammation. IL-6 mRNA expression did not occur in the liver of hepatectomized rats as judged from Northern blotting experiments using an IL-6 riboprobe. These results suggest that if IL-6 is implicated in hepatic regeneration, this cytokine is not produced by the regenerating liver and must be delivered exogenously to the liver to modulate hepatic regeneration.
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页码：159 / 162
页数：4
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