A case of long-undiagnosed Common Primary Immunodeficiency in adulthood

被引：0
作者：
Tirotta, D. [1 ]
Durante, V. [1 ]
机构：
[1] Osped Cervesi Cattolica, AUSL Romagna, Med Interna, Via Beethoven 1, I-47841 Cattolica, RN, Italy
来源：
EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY | 2014年 / 46卷 / 05期
关键词：
Immunodeficiency; Common Variable Immunodeficiency; Primary Immunodeficiency Disorders;
D O I：
暂无
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Common Variable Immunodeficiency (CVID) is one of the most common causes of Primary Immunodeficiency Disorders (PIDs) and of Primary Hypogammaglobulinemia in adulthood. Clinical features include variable combinations of infectious diseases, autoimmune diseases, lymphoproliferative disorders and gastrointestinal diseases. In this case report, delayed detection of the disease had a negative prognostic impact, despite prompt antibiotic and replacement therapy. The unfavourable prognosis was due to multi-organ failure (namely lungs, heart and liver) and to a number of chronic and acute infectious diseases.
引用
收藏
页码：184 / 188
页数：5
相关论文
共 10 条
[1]   Dissecting the Group of Common Variable Immunodeficiency Disorders [J].
Aslam, Aamir ;
Chapel, Helen .
CLINICAL INFECTIOUS DISEASES, 2009, 49 (09) :1339-1340
[2]   Evaluation of the adult with suspected immunodeficiency [J].
Azar, Antoine E. ;
Ballas, Zuhair K. .
AMERICAN JOURNAL OF MEDICINE, 2007, 120 (09) :764-768
[3]   Late onset of primary immune deficiencies [J].
Bussone, Guillaume ;
Mouthon, Luc .
PRESSE MEDICALE, 2010, 39 (02) :196-207
[4]   Common variable immunodeficiency disorders: division into distinct clinical phenotypes [J].
Chapel, Helen ;
Lucas, Mary ;
Lee, Martin ;
Bjorkander, Janne ;
Webster, David ;
Grimbacher, Bodo ;
Fieschi, Claire ;
Thon, Vojtech ;
Abedi, Mohammad R. ;
Hammarstrom, Lennart .
BLOOD, 2008, 112 (02) :277-286
[5]   Adult-onset primary hypogammaglobulinemia [J].
Fieschi, Claire ;
Malphettes, Marion ;
Galicier, Lionel ;
Oksenhendler, Eric .
PRESSE MEDICALE, 2006, 35 (05) :887-894
[6]   The European internet-based patient and research database for primary immunodeficiencies: results 2006-2008 [J].
Gathmann, B. ;
Grimbacher, B. ;
Beaute, J. ;
Dudoit, Y. ;
Mahlaoui, N. ;
Fischer, A. ;
Knerr, V. ;
Kindle, G. .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2009, 157 :3-11
[7]   Late-Onset Combined Immune Deficiency: A Subset of Common Variable Immunodeficiency with Severe T Cell Defect [J].
Malphettes, Marion ;
Gerard, Laurence ;
Carmagnat, Maryvonnick ;
Mouillot, Gael ;
Vince, Nicolas ;
Boutboul, David ;
Berezne, Alice ;
Nove-Josserand, Raphaele ;
Lemoing, Vincent ;
Tetu, Laurent ;
Viallard, Jean-Francois ;
Bonnotte, Bernard ;
Pavic, Michel ;
Haroche, Julien ;
Larroche, Claire ;
Brouet, Jean-Claude ;
Fermand, Jean-Paul ;
Rabian, Claire ;
Fieschi, Claire ;
Oksenhendler, Eric .
CLINICAL INFECTIOUS DISEASES, 2009, 49 (09) :1329-1338
[8]   Morbidity and mortality in common variable immune deficiency over 4 decades [J].
Resnick, Elena S. ;
Moshier, Erin L. ;
Godbold, James H. ;
Cunningham-Rundles, Charlotte .
BLOOD, 2012, 119 (07) :1650-1657
[9]  
Sahn S, 2012, UPTODATE
[10]   Common variable immunodeficiency - an update [J].
Salzer, Ulrich ;
Warnatz, Klaus ;
Peter, Hans Hartmut .
ARTHRITIS RESEARCH & THERAPY, 2012, 14 (05)
1