ORIGIN OF RAISED MATERNAL SERUM ALPHA-FETOPROTEIN LEVELS IN 2ND-TRIMESTER OLIGOHYDRAMNIOS

被引：5
作者：
LOS, FJ
BEEKHUIS, JR
MARRINK, J
HAGENAARS, AM
REUSS, A
SACHS, ES
JAHODA, MGJ
WLADIMIROFF, JW
机构：
[1] UNIV HOSP GRONINGEN,DEPT GYNAECOL & OBSTET,GRONINGEN,NETHERLANDS
[2] UNIV HOSP GRONINGEN,DEPT INTERNAL MED,GRONINGEN,NETHERLANDS
[3] NATL INST PUBL HLTH & ENVIRONM PROTECT,DEPT TERATOL ENDOCRINOL & PERINATAL SCREENING,BILTHOVEN,NETHERLANDS
[4] ERASMUS UNIV,UNIV HOSP DIJKZIGT,DEPT OBSTET & GYNAECOL,3000 DR ROTTERDAM,NETHERLANDS
来源：
PRENATAL DIAGNOSIS | 1992年 / 12卷 / 01期
关键词：
OLIGOHYDRAMNIOS; ALPHA-FETOPROTEIN; CONCANAVALIN-A; FETAL MEMBRANES;
D O I：
10.1002/pd.1970120106
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Concanavalin A (Con A) subtyping of alpha-fetoprotein (AFP) revealed higher concentrations of AFP non-reactive with Con A in sera of 12 pregnant women with second-trimester oligohydramnios and raised total serum AFP levels than in sera of 42 pregnant women with raised total serum AFP levels and a normal amniotic fluid volume. This suggests that in oligohydramnios the origin of excess AFP in the maternal compartment is amniotic fluid. It is proposed that oligohydramnios and the associated raised maternal serum AFP levels are caused by damage of the fetal membranes prior to 16 weeks of gestation resulting in leakage of amniotic fluid to the decidual tissue and resorption in the maternal circulation.
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收藏
页码：39 / 45
页数：7
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