IDENTIFICATION OF A GP63 SURFACE GLYCOPROTEIN IN LEISHMANIA-TARENTOLAE

被引：15

作者：

CAMPBELL, DA

KURATH, U

FLEISCHMANN, J

机构：

[1] UNIV CALIF LOS ANGELES,W LOS ANGELES MED CTR,INST MOLEC BIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,W LOS ANGELES MED CTR,DEPT MED,LOS ANGELES,CA 90024

来源：

FEMS MICROBIOLOGY LETTERS | 1992年 / 96卷 / 01期

关键词：

LEISHMANIA-MAJOR; LEISHMANIA-TARENTOLAE; GLYCOPROTEIN GP63 GENE; PROMASTIGOTE SURFACE PROTEASE;

D O I：

10.1111/j.1574-6968.1992.tb05398.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The promastigote stage of most if not all Leishmania species possesses an abundant surface glycoprotein of 63 kDa (gp63) that has protease activity. We show that the lizard parasite Leishmania tarentolae appears to lack the surface protease activity. L. tarentolae does, however, possess an approximately 63-kDa molecule that is antigenically cross-reactive with the L. major gp63. Additionally, the genome of L. tarentolae contains sequences that hybridise at high stringency to a L. major gp63 gene probe.

引用

页码：89 / 92

页数：4

共 12 条

[1]

BORDIER C, 1981, J BIOL CHEM, V256, P1604

[2] IDENTIFICATION OF THE PROMASTIGOTE SURFACE PROTEASE IN 7 SPECIES OF LEISHMANIA [J].