ANALGESIC, ANTIPYRETIC AND ANTIINFLAMMATORY PROPERTIES OF EUPHORBIA-HIRTA

被引:128
作者
LANHERS, MC
FLEURENTIN, J
DORFMAN, P
MORTIER, F
PELT, JM
机构
[1] UNIV METZ,CTR SCI ENVIRONNEMENT,PHARMACOGNOSIE LAB,1 RUE RECOLLETS,F-57000 METZ,FRANCE
[2] UNIV NANCY,PHARMACOGNOSIE LAB,F-5400 NANCY,FRANCE
[3] LABS DOLISOS,F-75003 PARIS,FRANCE
[4] SOC FRANCAISE ETHNOPHARMACOL,F-57000 METZ,FRANCE
关键词
EUPHORBIA-HIRTA; CENTRAL ANALGESICS; ANTIPYRETICS; ANTIINFLAMMATORY COMPOUNDS;
D O I
10.1055/s-2006-960079
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedative effect, associated with anxiolytic effects. This study leads us to the conclusion that this plant extract exerts central analgesic properties. Such a dose-dependent action was obtained against chemical (writhing test) and thermic (hot plate test) stimuli, respectively, from the doses of 20 and 25 mg/kg and it was inhibited by a naloxone pretreatment, a specific morphinic antagonist compound. An antipyretic activity was obtained at the sedative doses of 100 and 400 mg/kg, on the yeast-induced hyperthermia. Finally, significant and dose-dependent anti-inflammatory effects were observed on an acute inflammatory process (carrageenan-induced edema test in rats) from the dose of 100 mg/kg. On the other hand, plant extract remained inactive on chronic processes such as Freund's adjuvant-induced rheumatoid arthritis, after a chronic treatment during fourteen days at the daily dose of 200 or 400 mg/kg; however, if inefficacy was observed on rat backpaws edema and on loss of weight, the aqueous extract reduced the inflammatory hyperalgia.
引用
收藏
页码:225 / 231
页数:7
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