2-[3-(Aziridin-1-yl)-2-hydroxypropyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part III)

被引：1

作者：

Spreitzer, Helmut ^{[1
]}

Puschmann, Christiane ^{[1
]}

机构：

[1] Univ Vienna, Fac Life Sci, Dept Drug & Nat Prod Synth, Althanstr 14, A-1090 Vienna, Austria

来源：

MOLBANK | 2012年 / 03期

关键词：

pyrrole; DNA-alkylation; anticancer;

D O I：

10.3390/M772

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An hydroxypropyl-aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively.

引用

页数：4

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