ACROMELIC ACID-C - A NEW TOXIC CONSTITUENT OF CLITOCYBE-ACROMELALGA - AN EFFICIENT ISOLATION OF ACROMELIC ACIDS

被引：39

作者：

FUSHIYA, S

SATO, S

KANAZAWA, T

KUSANO, G

NOZOE, S

机构：

[1] Pharmaceutical Institute, Tohoku University, Sendai, 980, Aobayama

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(00)97501-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The neurotoxic amino acids, acromelic acids A and B were efficiently isolated from the poisonous mushroom Clitocybe acromelalga, accompanied by a new toxic analogue, acromelic acid C. The structure of acromelic acid C was elucidated to be 1 by comparison of the spectral data with those of acromelic acids A and B. Acromalic acid C exhibited a lethal toxicity to the mice at a dose of 10 mg/kg. © 1990.

引用

页码：3901 / 3904

页数：4

共 6 条

[1] ACROMELIC ACID IS A MUCH MORE POTENT EXCITANT THAN KAINIC ACID OR DOMOIC ACID IN THE ISOLATED RAT SPINAL-CORD [J].