EFFECT OF SOMATOSTATIN ON ABNORMAL GROWTH-HORMONE AND PROLACTIN SECRETION IN PATIENTS WITH THE CARCINOID-SYNDROME

被引：11
作者：
GOMEZPAN, A
SCANLON, MF
THORNER, MO
REES, LH
SCHALLY, AV
HALL, R
BESSER, GM
机构：
[1] ROYAL VICTORIA INFIRM,DEPT MED,ENDOCRINE UNIT,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
[2] ST BARTHOLOMEWS HOSP,DEPT ENDOCRINOL,LONDON EC1A 7BE,ENGLAND
[3] ST BARTHOLOMEWS HOSP,DEPT CHEM PATHOL,LONDON EC1A 7BE,ENGLAND
[4] TULANE UNIV,NEW ORLEANS,LA 70118
[5] VET ADM HOSP,NEW ORLEANS,LA 70140
来源：
CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 06期
关键词：
D O I：
10.1111/j.1365-2265.1979.tb02117.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Growth hormone (GH) secretion has been studied in two patients with the carcinoid syndrome during glucose loading and growth hormone‐release inhibiting hormone (GHRIH, somatostatin) infusion. Both patients had elevated fasting GH levels which were not suppressed by glucose; GH levels fell rapidly during GHRIH infusion. One patient also had hyperprolactinaemia with galactorrhoea and the prolactin (PRL) levels were unaltered by GHRIH. The association between carcinoid tumours and abnormalities of GH and PRL secretion is discussed. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码：575 / 581
页数：7
相关论文
共 32 条
[11]   SOLID-PHASE SYNTHESIS OF GROWTH HORMONE RELEASE INHIBITING FACTOR [J].
COY, DH ;
COY, EJ ;
ARIMURA, A ;
SCHALLY, AV .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 54 (04) :1267-1273
[12]   BRONCHIAL CARCINOID TUMOR WITH ACROMEGALY IN 2 PATIENTS [J].
DABEK, JT .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1974, 38 (02) :329-333
[13]   GROWTH-HORMONE AND PROLACTIN SECRETION IN CARCINOID-SYNDROME [J].
FELDMAN, JM ;
PLONK, JW ;
BIVENS, CH ;
LEBOVITZ, HE ;
HANDWERGER, S .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1975, 269 (03) :333-347
[14]   INHIBITORY EFFECT OF SEROTONIN ANTAGONISTS ON GROWTH-HORMONE RELEASE IN ACROMEGALIC PATIENTS [J].
FELDMAN, JM ;
PLONK, JW ;
BIVENS, CH .
CLINICAL ENDOCRINOLOGY, 1976, 5 (01) :71-78
[15]   ACTION OF GROWTH-HORMONE RELEASE INHIBITORY HORMONE ON PROLACTIN-RELEASE IN RAT PITUITARY CELL-CULTURES [J].
GRANT, NH ;
SARANTAKIS, D ;
YARDLEY, JP .
JOURNAL OF ENDOCRINOLOGY, 1974, 61 (01) :163-164
[16]  
HALL R, 1973, LANCET, V2, P581
[17]   IMMUNOASSAY OF SERUM GROWTH HORMONE IN ACROMEGALIC PATIENTS [J].
HARTOG, M ;
GAAFAR, MA ;
MEISSER, B ;
FRASER, R .
BRITISH MEDICAL JOURNAL, 1964, 2 (541) :1229-&
[18]   EFFECT OF 5-HYDROXYTRYPTOPHAN (5-HTP) ON GROWTH-HORMONE AND ACTH RELEASE IN MAN [J].
IMURA, H ;
NAKAI, Y ;
YOSHIMI, T .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1973, 36 (01) :204-206
[19]   EFFECT OF L-DOPA ON PLASMA GROWTH-HORMONE, INSULIN, AND THYROXINE [J].
KANSAL, PC ;
TALBERT, OR ;
BUSE, MG ;
BUSE, J .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1972, 34 (01) :99-+
[20]   STIMULATORY AND INHIBITORY EFFECTS OF PURIFIED HYPOTHALAMIC EXTRACTS ON GROWTH HORMONE RELEASE FROM RAT PITUITARY IN VITRO [J].
KRULICH, L ;
DHARIWAL, AP ;
MCCANN, SM .
ENDOCRINOLOGY, 1968, 83 (04) :783-&
1234