HEPATITIS-B CORE ANTIBODY IN VOLUNTEER BLOOD-DONORS - COMPARISON OF RADIOIMMUNOASSAY AND INDIRECT IMMUNOFLUORESCENCE

被引：8

作者：

KATCHAKI, JN ^{[1
]}

SIEM, TH ^{[1
]}

BROUWER, R ^{[1
]}

机构：

[1] MUNICIPAL HOSP, BLOOD BANK, ARNHEM, NETHERLANDS

来源：

JOURNAL OF MEDICAL VIROLOGY | 1979年 / 3卷 / 04期

关键词：

anti‐HBc; blood donors; post‐transfusion hepatitis B;

D O I：

10.1002/jmv.1890030405

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The results of a pilot study on the prevalence of anti‐HBc in HBsAg negative volunteer blood donors are presented. Two techniques for anti‐HBc determination were compared — radio—immunoassay (RIA) and indirect immunofluorescence (IF). In a panel of 56 sera with known HBV markers, RIA was found to be significantly more sensitive than IF, and both techniques were specific. Out of 2,000 HBsAg negative blood donor sera tested by RIA,46 (2.3%) were found positive for anti‐HBc. In 24/24 sera, the specificity of the anti‐HBc was confirmed. Also 37/46 (80.4%) anti‐HBc positives were found positive for anti‐HBs, leaving 9/2, OOC (0.4%) blood donors positive only for anti‐HBc. It is concluded that it would be premature to advocate the introduction of anti‐HBc as a routine screening test of blood donors. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company

引用

页码：275 / 280

页数：6

共 12 条

[1]

ALMEIDA JD, 1971, LANCET, V2, P1225

[2] DUALITY OF HEPATITIS B ANTIGEN AND ITS ANTIBODY .1. IMMUNOFLUORESCENCE STUDIES [J].