CORRELATION AMONG SECONDARY STRUCTURE, AMYLOID PRECURSOR PROTEIN ACCUMULATION, AND NEUROTOXICITY OF AMYLOID BETA(25-35) PEPTIDE AS ANALYZED BY SINGLE ALANINE SUBSTITUTION

被引：45

作者：

SATO, K ^{[1
]}

WAKAMIYA, A ^{[1
]}

MAEDA, T ^{[1
]}

NOGUCHI, K ^{[1
]}

TAKASHIMA, A ^{[1
]}

IMAHORI, K ^{[1
]}

机构：

[1] KITASATO UNIV,DEPT PHYS,SAGAMIHARA,KANAGAWA 228,JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1995年 / 118卷 / 06期

关键词：

AGGREGATION; AMYLOID BETA PROTEIN; BETA-SHEET CONFORMATION; HYDROPHOBICITY; NEUROTOXICITY;

D O I：

10.1093/oxfordjournals.jbchem.a124994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structure-neurotoxicity relationships of amyloid beta(25-35) peptide were studied by replacing each amino acid with Ala, In contrast to the general tendency in hydrophobicity-toxicity relationships, replacement of Asn(27) yielded a more hydrophobic but less toxic analog and that of Met(35) gave a less hydrophobic but more toxic one, Sedimentation profiles and CD spectra indicated that peptide aggregation via intermolecular beta-sheet formation is essential for the neurotoxicity of amyloid beta(25-35) peptide, The correlation between neurotoxicity and amyloid precursor protein accumulation suggested that the latter is one of the pathways of the neuronal death caused by amyloid beta protein.

引用

页码：1108 / 1111

页数：4

共 15 条

[1] SOLUTION STRUCTURES OF BETA PEPTIDE AND ITS CONSTITUENT FRAGMENTS - RELATION TO AMYLOID DEPOSITION [J].