PYRAZOLE-QUINOLONE-ISONIAZID HYBRIDS: SYNTHESIS, CHARACTERIZATION AND IN VITRO EVALUATION AS A NEW CLASS OF ANTIMICROBIAL AND ANTITUBERCULAR AGENTS

A series of pyrazole-quinoline-isoniazid hybrids were designed based on molecular hybridization technique. The title compounds were synthesized via one-pot three component reaction between 3-substituted-1H-pyrazole-4-carbaldehydes, N'-(5,5-(un)substituted-3-oxocyclohex-1-enyl) isonicotinohydrazide and malononitrile or ethyl/isopropyl cyanoacetates in ethanol containing a catalytic amount of triethylamine. All derivatives were elucidated by H-1 NMR, C-13 NMR, FT-IR, elemental analysis and mass spectral data. All the newly synthesized compounds were screened for their antimicrobial and antitubercular activities.