LITHIATION AND ELECTROPHILIC SUBSTITUTION OF 8-CHLORODIBENZ[B,F][1,4]-OXAZEPINE-10-TERT-BUTYLCARBAMATE - THE PREPARATION OF NOVEL FUSED HETEROCYCLIC-DERIVATIVES OF 8-CHLORODIBENZOXAZEPINE

被引：1

作者：

LI, JJ

HAGEN, TJ

CHRUSCIEL, RA

NORTON, MB

TSYMBALOV, S

HALLINAN, EA

REITZ, DB

机构：

[1] Monsanto Company, St Louis, Missouri, 63198

[2] Department of Chemistry, Searle Research & Development, Skokie, Illinois

[3] Department of Biochemistry, Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 06期

关键词：

D O I：

10.1002/jhet.5570310670

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lithiation of 8-chlorodibenz[b,f][1,4]oxazepine-10-tert-butylcarbamate (1) is described. Electrophilic substitution of the resulting N-Boc dibenzoxazepine alpha-lithioamine 2 with ketones, aldehydes, nitriles, isocyanates and imines, followed by an in-situ cyclization, gave fused carbamates 5-26, fused 2H-imidazol-2-ones 27-29, fused hydantoins 30-32, and fused ureas 33-35, respectively, in 11-66% yield.

引用

页码：1689 / 1696

页数：8