Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach

被引:27
|
作者
Fagundes, Christopher [1 ,2 ,3 ]
LeRoy, Angie [4 ]
Karuga, Maryanne [5 ]
机构
[1] Rice Univ, Dept Psychol, Houston, TX 77005 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Symptoms Res, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Psychiat, Houston, TX 77030 USA
[4] Univ Houston, Dept Psychol, Houston, TX 77004 USA
[5] Dillard Univ, Dept Sci Technol Engn & Math, New Orleans, LA 70122 USA
关键词
breast cancer survivors; inflammation; SES; chronic stressors; proinflammatory cytokine production; recurrence; fatigue; depression;
D O I
10.3390/jpm5030280
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Being diagnosed and treated for breast cancer is emotionally and physically challenging. Breast cancer is the most commonly diagnosed cancer and the second leading cause of death for women in the United States. Accordingly, women with a breast cancer history are the largest group of female cancer survivors. Psychological stress substantially augments adverse autonomic, endocrine, and immune discharge, including enhanced production of proinflammatory cytokines. Importantly, inflammation is a key biological mechanism underlying the symptom cluster of pain, depression, fatigue, and sleep disturbances; there is also good evidence that inflammation contributes to breast cancer recurrence. Stress may exert direct effects on psychological and physiological risk processes. In this review, we take a biobehavioral approach to understanding predictors and mechanisms underlying somatic symptoms in breast cancer survivors.
引用
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页码:280 / 295
页数:16
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