THE 3'-UNTRANSLATED REGIONS FROM THE TRYPANOSOMA-BRUCEI PHOSPHOGLYCERATE KINASE-ENCODING GENES MEDIATE DEVELOPMENTAL REGULATION

被引：49
|
作者：
BLATTNER, J [1 ]
CLAYTON, CE [1 ]
机构：
[1] UNIV HEIDELBERG,ZENTRUM MOLEK BIOL,D-69120 HEIDELBERG,GERMANY
来源：
GENE | 1995年 / 162卷 / 01期
关键词：
POSTTRANSCRIPTIONAL REGULATION; KINETOPLASTIDAE; GLYCOLYSIS; TRANSFECTION; POLYADENYLATION;
D O I：
10.1016/0378-1119(95)00366-E
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The phosphoglycerate kinase (PGK)-encoding genes of Trypanosoma brucei are transcribed in a polycistronic fashion, but the mRNAs encoding the three PGK isozymes show differing developmental regulation. We demonstrate here that the 3'-untranslated regions of the major cytoplasmic and glycosomal PGK isozymes are capable of conferring the anticipated types of regulation on a transfected reporter gene.
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页码：153 / 156
页数：4
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