MOLECULAR-GENETICS OF ANTIGENIC VARIATION

被引:69
作者
BORST, P
机构
[1] The Netherlands Cancer Institute, 1066 CX Amsterdam
来源
IMMUNOPARASITOLOGY TODAY-A COMBINED ISSUE OF IMMUNOLOGY TODAY AND PARASITOLOGY TODAY | 1991年 / 03期
关键词
D O I
10.1016/S0167-5699(05)80009-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antigenic variation is one of the most effective strategies developed by parasites to escape immune destruction. It requires a large wardrobe of surface coats and mechanisms to exchange one coat for an unrelated one. The molecular principles of antigenic variation are now largely known in the bacterial species Borrelia and Neisseria and in the protozoa of the African trypanosome group and these three examples are discussed here by Piet Borst. © 1991 Elsevier Science Publishers Ltd, UK.
引用
收藏
页码:A29 / A33
页数:5
相关论文
共 44 条
[1]  
AGABIAN N, 1989, ANN NY ACAD SCI, V569, P127, DOI 10.1111/j.1749-6632.1989.tb27363.x
[2]   ORDERED APPEARANCE OF ANTIGENIC VARIANTS OF AFRICAN TRYPANOSOMES EXPLAINED IN A MATHEMATICAL-MODEL BASED ON A STOCHASTIC SWITCH PROCESS AND IMMUNE-SELECTION AGAINST PUTATIVE SWITCH INTERMEDIATES [J].
AGUR, Z ;
ABIRI, D ;
VANDERPLOEG, LHT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9626-9630
[3]   INSTABILITY OF THE TRYPANOSOMA-BRUCEI-RHODESIENSE METACYCLIC VARIABLE ANTIGEN REPERTOIRE [J].
BARRY, JD ;
CROWE, JS ;
VICKERMAN, K .
NATURE, 1983, 306 (5944) :699-701
[4]   GAMES PARASITES PLAY - HOW PARASITES EVADE IMMUNE SURVEILLANCE [J].
BLOOM, BR .
NATURE, 1979, 279 (5708) :21-26
[5]   PROGRAMMED GENE REARRANGEMENTS ALTERING GENE-EXPRESSION [J].
BORST, P ;
GREAVES, DR .
SCIENCE, 1987, 235 (4789) :658-667
[6]   DISCONTINUOUS TRANSCRIPTION AND ANTIGENIC VARIATION IN TRYPANOSOMES [J].
BORST, P .
ANNUAL REVIEW OF BIOCHEMISTRY, 1986, 55 :701-732
[7]   INGESTION OF PROTEIN MOLECULES BY BLOOD FORMS OF TRYPANOSOMA RHODESIENSE [J].
BROWN, KN ;
ARMSTRONG, JA ;
VALENTINE, RC .
EXPERIMENTAL CELL RESEARCH, 1965, 39 (01) :129-+
[8]   RELEASE OF THE VARIANT SURFACE GLYCOPROTEIN DURING DIFFERENTIATION OF BLOOD-STREAM TO PROCYCLIC FORMS OF TRYPANOSOMA-BRUCEI [J].
BULOW, R ;
NONNENGASSER, C ;
OVERATH, P .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 32 (01) :85-92
[9]   CLONAL POLYMORPHISMS OF OUTER-MEMBRANE PROTEIN-OSPB OF BORRELIA-BURGDORFERI [J].
BUNDOC, VG ;
BARBOUR, AG .
INFECTION AND IMMUNITY, 1989, 57 (09) :2733-2741
[10]   TRYPANOSOMA-RHODESIENSE INFECTION IN CONGENITALLY ATHYMIC (NUDE) MICE [J].
CAMPBELL, GH ;
ESSER, KM ;
PHILLIPS, SM .
INFECTION AND IMMUNITY, 1978, 20 (03) :714-720