LYMPHOCYTE SUB-POPULATIONS IN MAN - CHARACTERIZATION OF HUMAN KILLER CELLS AGAINST ALLOGENEIC TARGETS SENSITIZED WITH HLA ANTIBODIES

被引：8

作者：

JOHNSEN, HE

MADSEN, M

机构：

[1] AARHUS UNIV,AARHUS KOMMUNE HOSP,BLOOD BANK,DK-8000 AARHUS C,DENMARK

[2] AARHUS UNIV,AARHUS KOMMUNE HOSP,BLOOD GROUPING LAB,DK-8000 AARHUS C,DENMARK

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1979.tb03065.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human killer cells mediating antibody‐dependent cytotoxicity against allogeneic lymphoblasts presensitized with HLA antibodies have been studied by rosette fractionation experiments. Enriched and/or depleted cell suspensions have been tested in dose–response studies. Two different populations can act as killer cells. The major cytotoxic capacity is retained among T cells with high‐avidity Fc receptors, whereas a minor cytotoxic capacity was found among non‐T cells with high‐avidity Fc receptors. These two populations have different dose‐response curves, indicating different effector mechanisms. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：429 / 440

页数：12

共 32 条

[1]

CANTY TG, 1971, J IMMUNOL, V106, P200

[2]

Cerottini J C, 1974, Adv Immunol, V18, P67, DOI 10.1016/S0065-2776(08)60308-9

[3] ANTIBODY-DEPENDENT CELL CYTOTOXICITY (ADCC) - CHARACTERIZATION OF KILLER CELLS IN HUMAN LYMPHOID ORGANS [J].