MODULATION OF ENDOTHELIN RECEPTOR EXPRESSION IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS BY INTERLEUKIN-1-BETA

被引：16
|
作者：
NEWMAN, P [1 ]
KAKKAR, VV [1 ]
KANSE, SM [1 ]
机构：
[1] THROMBOSIS RES INST,LONDON SW3 6LR,ENGLAND
来源：
FEBS LETTERS | 1995年 / 363卷 / 1-2期
关键词：
ENDOTHELIN RECEPTOR; INTERLEUKIN-1-BETA; SMOOTH MUSCLE CELL; ATHEROSCLEROSIS;
D O I：
10.1016/0014-5793(95)00308-V
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endothelin may play a role in atherosclerosis as it causes smooth muscle cell proliferation and its levels are elevated in patients with atherosclerosis. We report that interleukin-lp is a potent inducer of endothelin receptor expression in cultured human vascular smooth muscle cells. The effect is dose- and time-dependent and is due to an increase in receptor number. Endothelin receptor mRNA levels are also elevated. Interleukin-1 beta is a major regulator of endothelin release so, together with its effects on endothelin receptors, it may be responsible for a generalized activation of the endothelin system in diseased vessels.
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页码：161 / 164
页数：4
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