A DOUBLE-BLIND-STUDY OF MISOPROSTOL (SC-29333) IN THE HEALING OF DUODENAL-ULCER

被引：1

作者：

AHMED, WU

QURESHI, HM

ALAM, E

ZUBERI, SJ

机构：

[1] PMRC Research Centre, Jinnah Postgraduate Medical Centre, Karachi

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 1991年 / 6卷 / 02期

关键词：

DUODENAL ULCER; MISOPROSTOL; PROSTAGLANDIN;

D O I：

10.1111/j.1440-1746.1991.tb01463.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In a double-blind randomized placebo controlled trial, 50 patients with endoscopically confirmed duodenal ulcer were treated with either misoprostol 200-mu-g or placebo in q.i.d. doses for 4-8 weeks. Of 25 patients in the placebo group, four defaulted and two were withdrawn due to worsening of symptoms. Of 25 misoprostol-treated cases, 17 cases (68%) and 21 cases (84%) healed at 4 and 8 weeks respectively, compared with three (14%) and five (24%) of the 21 placebo-treated cases (P < 0.001). Except for diarrhoea in 2 patients in each group and itching in one with misoprostol, no serious side effects were noted.

引用

页码：179 / 180

页数：2

共 9 条

[1]

AKDAMAR K, 1982, AM J GASTROENTEROL, V77, P902

[2] A MULTICENTER, RANDOMIZED, DOUBLE-BLIND-STUDY COMPARING A DAILY BEDTIME ADMINISTRATION OF FAMOTIDINE AND RANITIDINE IN SHORT-TERM TREATMENT OF ACTIVE DUODENAL-ULCER [J].

ALCALASANTAELLA, R ;

GUARDIA, J ;

PAJARES, J ;

PIQUE, J ;

PITA, L ;

ALVAREZ, E ;

CASTELLANOS, P ;

GUARNER, L ;

ORTIZ, J ;

PESQUERA, R ;

VARGAS, V ;

RUIZCAPELLAN, R .

DIGESTION, 1989, 42 (02) :79-85

[3]

BRAND DL, 1985, DIGESTIVE DISEASES S, V30, P147

[4]

BRIGHTASARE P, 1986, DIGESTIVE DISEASES S, V31, P63

[5]

HERTING RL, 1985, DIGESTIVE DISEASES S, V30, P185

[6] EFFECT OF SYNTHETIC PROSTAGLANDIN-E1 ANALOG ON ASPIRIN-INDUCED GASTRIC BLEEDING AND SECRETION [J].

HUNT, JN ;

SMITH, JL ;

JIANG, CL ;

KESSLER, L .

DIGESTIVE DISEASES AND SCIENCES, 1983, 28 (10) :897-902

[7]

LAM SK, 1986, DIGESTIVE DISEASES S, V31, P68

[8]

NICHOLSON PA, 1985, DIGESTIVE DISEASES S, V30, P171

[9]

Qureshi H, 1989, J Pak Med Assoc, V39, P104

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