FLOW CYTOMETRIC ANALYSIS OF DNA PLOIDY IN 62 PATIENTS WITH WILMS-TUMOR

被引：0

作者：

MISRA, D ^{[1
]}

ROHATGI, M ^{[1
]}

MATHUR, M ^{[1
]}

SHARMA, S ^{[1
]}

机构：

[1] ALL INDIA INST MED SCI,DEPT PAEDIAT SURG,NEW DELHI 110029,INDIA

来源：

PEDIATRIC SURGERY INTERNATIONAL | 1992年 / 7卷 / 01期

关键词：

NEPHROBLASTOMA; DNA; PLOIDY; FLOW CYTOMETRY;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Flow cytometric analysis of DNA ploidy was done on nuclei extracted from paraffin-embedded tissue blocks from 62 patients with Wilms' tumor, the largest series reported to date. Thirty-eight tumors were aneuploid and 24 were diploid; there were no tetraploids. Sixty-seven percent of the diploids and 44.7% of the aneuploids survived; the difference was statistically significant (P < 0.01). The 2 congenital mesoblastic nephromas were diploid; the only 2 adult patients were aneuploid. Aneuploids comprised 75% of those presenting in stage III/IV and 75% of the anaplastic tumors. Genetic heterogeneity, never before reported in Wilms' tumor, was found in 2 patients. Aneuploidy was an ominous prognostic factor, particularly when combined with tumor stage and histological grade.

引用

页码：51 / 54

页数：4