HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CIMETIDINE IN SERUM

被引：29
作者：
SOLDIN, SJ
FINGOLD, DR
FENJE, PC
MAHON, WA
机构：
[1] Department of Biochemistry, Hospital for Sick Children, Toronto, ON
[2] Department of Medicine, Toronto General Hospital, Toronto, ON
[3] Departments of Clinical Biochemistry and Pharmacology, University of Toronto, Toronto, ON
来源：
THERAPEUTIC DRUG MONITORING | 1979年 / 1卷 / 03期
关键词：
Cimetidine; High pressure liquid chromatography; Serum concentrations;
D O I：
10.1097/00007691-197901030-00010
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
A rapid and reliable micro procedure for the high pressure liquid chromatographic analysis of Cimetidine, Nʺ-cyano-Af-methyl-Nʹ-[2-[[(5-methyl-lH-imidazol-4-yl)methyl]thio]ethyl]guanidine, in serum or plasma is described. The percentage analytical recovery of Cimetidine and internal standard (β-hydroxypropyl-theophylline) was 65 and 99%, respectively. The between-day precision of the method at Cimetidine serum concentrations of 2,000, 1,000, and 500 µg/liter yielded coefficients of variation of 10.6, 11.5, and 10.6%, respectively. The method has been used in preliminary studies to determine the serum concentrations in patients receiving the drug by both the oral and intravenous route. © 1979 Raven Press, New York.
引用
收藏
页码：371 / 379
页数：9
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